Inflammasome and intestinal mucosal immunity

HUANG Jiaming1; 2; *; YANG Dongxue1; *; LI Xiaoxi1; YANG Shuo1

doi:10.3969/j.issn.1673-6184.2019.01.007

Journal of Microbes and Infections >

2019 , Vol. 14 >Issue 2: 113 - 123

DOI: https://doi.org/10.3969/j.issn.1673-6184.2019.01.007

Review

Inflammasome and intestinal mucosal immunity

HUANG Jiaming1 ,
2 ,
* ,
YANG Dongxue1 ,
* ,
LI Xiaoxi1 ,
YANG Shuo1

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1. Department of Immunology, Basic Medical Sciences, Nanjing Medical University, Nanjing 211100, Jiangsu Province, China; 2. Basic Medical Sciences, Nanjing Medical University, Nanjing 211100, Jiangsu Province, China

Received date: 2018-12-25

Online published: 2019-04-25

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Abstract

Intestine is the largest digestive organ of human, providing essential nutrients for growth. The intestinal immune system has unique immunological characteristics and plays a key role in resisting environmental toxins and protecting against potential invading pathogens. Inflammasome is important protein complexes of innate immune system, participating in host defense response to pathogens and maintaining intestinal immune homeostasis. In this review, the intestinal mucosal immune system and the role of inflammasome in intestinal mucosal immunity are summarized.

Key words： Intestinal epithelial cell; Microbiota; Intestinal mucosal immunity; Inflammasome

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HUANG Jiaming1 , 2 , * , YANG Dongxue1 , * , LI Xiaoxi1 , YANG Shuo1 . Inflammasome and intestinal mucosal immunity[J]. Journal of Microbes and Infections, 2019 , 14(2) : 113 -123 . DOI: 10.3969/j.issn.1673-6184.2019.01.007

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