Advances in research on the pathogenesis of plague

ZHANG Yi; ZHANG Haocheng

doi:doi:10.3969/j.issn.1673-6184.2019.06.002

Journal of Microbes and Infections >

2019 , Vol. 14 >Issue 6: 326 - 332

DOI: https://doi.org/doi:10.3969/j.issn.1673-6184.2019.06.002

Invited paper

Advances in research on the pathogenesis of plague

ZHANG Yi ,
ZHANG Haocheng

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Department of Infection Disease, Huashan Hospital, Fudan University, Shanghai 200040, China

Received date: 2019-11-26

Online published: 2019-12-25

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Abstract

The plague is a zoonotic disease caused by Yersinia pestis (Y. pestis). This bacterium Y. pestis has caused three deadly pandemic plague worldwide. Considering of expanding natural foci and frequent population turnover, prevention and control of plague is still grim. In this review, we mainly summarize the research progress on the virulence factors of Y. pestis, the mechanism of invasion, the intracellular replication and the dissemination mechanism in the host.

Key words： Plague; Yersinia pestis; Pathogenesis; Virulence factors

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ZHANG Yi , ZHANG Haocheng . Advances in research on the pathogenesis of plague[J]. Journal of Microbes and Infections, 2019 , 14(6) : 326 -332 . DOI: doi:10.3969/j.issn.1673-6184.2019.06.002

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