A super spreader is an infected individual who can disproportionally and efficiently transmit a specific pathogen to more than 10 naïve individuals, most of them are family members, health care workers, and other close-contact persons. Super spreaders were frequently reported in the recent outbreaks of infectious diseases, demonstrated that early discovery and management of super spreaders are critical measures to control epidemics. The formation, characterization and interventions of super spreaders are reviewed in this paper.