Re-understanding the potential mechanism of angiotensin converting enzyme 2 in severe acute respiratory syndrome coronavirus 2 pathogenicity from the perspective of gut microbiota

YANG Hao1; 2; WU Yonglin1; 2; RONG Xingyu1; 2; YAN Yuchen1; 2; WANG Huijing3; NIU Chen1; 2; ZHAO Chao1; 2

doi:10.3969/j.issn.1673-6184.2020.02.006

2020 , Vol. 15 >Issue 2: 104 - 107

DOI: https://doi.org/10.3969/j.issn.1673-6184.2020.02.006

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Re-understanding the potential mechanism of angiotensin converting enzyme 2 in severe acute respiratory syndrome coronavirus 2 pathogenicity from the perspective of gut microbiota

YANG Hao1 ,
2 ,
WU Yonglin1 ,
2 ,
RONG Xingyu1 ,
2 ,
YAN Yuchen1 ,
2 ,
WANG Huijing3 ,
NIU Chen1 ,
2 ,
ZHAO Chao1 ,
2

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1. MOE/NHC/CAMS Key Laboratory of Molecular Virology, School of Basic Medical Sciences, Shanghai Medical College, Fudan university, Shanghai 200032, China; 2. National Clinical Research Center on Aging and Medicine, Huashan Hospital, Shanghai 200040, China; 3. Laboratory of Neuropsychopharmacology, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China

Received date: 2020-02-11

Online published: 2020-04-25

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Abstract

Since the out breaking of coronavirus induced disease 2019 (COVID-19), the etiology and clinical manifestations of the disease have been reported and analyzed. There are many similarities between the etiology and clinical manifestations of the SARS in 2003. By comparing the similarities and differences between them, this study attempts to put forward and explore the potential mechanism of gut microbiota in patients, which may participate in its pathogenesis from the perspective of the shared receptor angiotensin converting enzyme 2 (ACE2). It may provide a possible way for in-depth study of the pathogenesis of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2) and the development of prediction indicators for severe pneumonia.

Key words： Gut microbiota; Coronavirus disease 2019; Severe acute respiratory syndrome; Angiotensin converting enzyme 2

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YANG Hao1 , 2 , WU Yonglin1 , 2 , RONG Xingyu1 , 2 , YAN Yuchen1 , 2 , WANG Huijing3 , NIU Chen1 , 2 , ZHAO Chao1 , 2 . Re-understanding the potential mechanism of angiotensin converting enzyme 2 in severe acute respiratory syndrome coronavirus 2 pathogenicity from the perspective of gut microbiota[J]. Journal of Microbes and Infections, 2020 , 15(2) : 104 -107 . DOI: 10.3969/j.issn.1673-6184.2020.02.006

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