Methicillin-resistant Staphylococcus aureus (MRSA) has become an increasingly invasive and prevalent pathogen. Due to chromosomal mediation, plasmid transfer, gene expression regulation, and active efflux systems, MRSA is resistant to a variety of antibiotics. When considering the issue from an ecological and evolutionary standpoint of view, it is evident that it is insufficient to solve the antibiotic dilemma only by antibiotics. This has forced people to look for a class of drugs that are completely different from existing antibiotics to treat MRSA. With the new information from immunology and biology, development of biological agents against MRSA infection have emerged. In this review, we summarize the latest advances in the treatment of MRSA infection with biologics, chemicals and traditional Chinese medicines.