Current research progress on host innate immune escaping by Salmonella

XU Nuo1; ZHOU Bangyue1; SHI Yi1; PAN Xingyuan1; 2; QIN Tao3; XU Zhengzhong4; YIN Yinyan1; 2; 4

doi:10.3969/j.issn.1673-6184.2020.05.010

Journal of Microbes and Infections >

2020 , Vol. 15 >Issue 5: 331 - 336

DOI: https://doi.org/10.3969/j.issn.1673-6184.2020.05.010

Review

Current research progress on host innate immune escaping by Salmonella

XU Nuo1 ,
ZHOU Bangyue1 ,
SHI Yi1 ,
PAN Xingyuan1 ,
2 ,
QIN Tao3 ,
XU Zhengzhong4 ,
YIN Yinyan1 ,
2 ,
4

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1. Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225009, Jiangsu Province, China; 2. Jiangsu Key laboratory of integrated traditional Chinese and Western Medicine for prevention and treatment of Senile Diseases, Yangzhou University, Yangzhou 225009, Jiangsu Province, China; 3. Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonosis, College of Veterinary Medicine, Yangzhou University, Yangzhou 225009, Jiangsu Province, China; 4. Jiangsu Key Laboratory of Zoonosis, Yangzhou University, Yangzhou 225009, Jiangsu Province, China

Received date: 2020-02-21

Online published: 2020-10-25

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Abstract

Salmonella is an important foodborne pathogen, which seriously threatens the global public health. The host innate immune response plays a significant role for resisting infection. Nowadays, Salmonella has evolved a series of strategies to escape the innate immune response for persistent infections. This review gives a detailed summarization on the new strategies of Salmonella, including receptors (TLRs, NLRs, RIPs), cytokines (IL-22 and IL-4) and mTOR signaling pathway-mediated immune escape.

Key words： Salmonella; Immune evasion; Toll like receptor; Nucleotide binding oligomerization domain like receptor; Cytokines; Mammalian target of rapamycin signaling pathway

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XU Nuo1 , ZHOU Bangyue1 , SHI Yi1 , PAN Xingyuan1 , 2 , QIN Tao3 , XU Zhengzhong4 , YIN Yinyan1 , 2 , 4 . Current research progress on host innate immune escaping by Salmonella[J]. Journal of Microbes and Infections, 2020 , 15(5) : 331 -336 . DOI: 10.3969/j.issn.1673-6184.2020.05.010

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