Research progress in mechanism of Fusobacterium nucleatum promoting colorectal cancer

CHEN Zixian; DUN Yiting; LIU Chang; CHEN Qian

doi:10.3969/j.issn.1673-6184.2021.02.008

Journal of Microbes and Infections >

2021 , Vol. 16 >Issue 2: 123 - 128

DOI: https://doi.org/10.3969/j.issn.1673-6184.2021.02.008

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Research progress in mechanism of Fusobacterium nucleatum promoting colorectal cancer

CHEN Zixian ,
DUN Yiting ,
LIU Chang ,
CHEN Qian

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Shanghai Jiao Tong University School of Medicine, Shanghai 200025

Received date: 2020-05-19

Online published: 2021-04-25

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Abstract

Fusobacterium nucleatum, a commensal bacterium in human oral cavity could cause opportunistic infections in certain conditions. Recently, the relationship between Fusobacterium nucleatum and colorectal cancer (CRC) has become a research focus. Clinical studies revealed that Fusobacterium nucleatum is implicated in CRC. Further studies on animals have proved that Fusobacterium nucleatum can promote the onset and progression of CRC and chemoresistance to treatments. This paper summarizes evidence for the association of Fusobacterium nucleatum with CRC and provides a comprehensive view of current mechanisms for the association.

Key words： Fusobacterium nucleatum; Colorectal cancer; Tumor microenvironment; Mechanism research

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CHEN Zixian , DUN Yiting , LIU Chang , CHEN Qian . Research progress in mechanism of Fusobacterium nucleatum promoting colorectal cancer[J]. Journal of Microbes and Infections, 2021 , 16(2) : 123 -128 . DOI: 10.3969/j.issn.1673-6184.2021.02.008

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