Mucormycosis is a rare invasive fungal disease with rapid progress and high fatality rate. In the past years, its incidence has shown an upward trend. Since December 2019, the corona virus disease 2019 (COVID-19) epidemic has been widespread worldwide and triggered the sixth international public health event. In this context, a large-scale outbreak of mucormycosis has occurred in India. This article reviewed the progress in the epidemiology, etiology, clinical manifestations, and diagnosis and treatment principles of mucormycosis. For the patients with suspected mucormycosis, imaging, fungal etiology, and molecular biological examinations should be completed as soon as possible, which are vital to realize early diagnosis and treatment and improve their clinical outcomes and prognosis.