Necroptosis is one of the regulated cell death mediated by receptor-interacting protein (kinase) (RIP/RIPK). It can be divided into the classical pathway that depends on RIPK1 and the non-classical pathway which is independent of RIPK1. RIPK3 and mixed lineage kinase domain-like (MLKL) are activated orderly through the above two ways, and finally induce necroptosis. With in-depth research, there are many forms of cell death have been discovered in the process of pathogenic microorganism infection. Pathogenic microorganisms cause various forms of cell death in the process of infection and the outcome of infection is highly dependent on the fate of cells. On the one hand, bacterial virulence factors cause lead to necroptosis of host cells; on the other hand, necroptosis is also an important way of host immune defense. It is of great significance to explore the interaction between bacteria and host for revealing the occurrence and development of infectious diseases.