Recent progress on cell receptors for SARS-CoV-2

CHEN Shenglin1*; XIAO Man2*; LI Zhaozhong3; XU Zhikai1; HAN Qi1; FENG Dongfang1; DENG Yan1; YIN Zuoming1

doi:10.3969/j.issn.1673-6184.2023.01.006

Journal of Microbes and Infections >

2023 , Vol. 18 >Issue 1: 46 - 54

DOI: https://doi.org/10.3969/j.issn.1673-6184.2023.01.006

Review

Recent progress on cell receptors for SARS-CoV-2

CHEN Shenglin1* ,
XIAO Man2* ,
LI Zhaozhong3 ,
XU Zhikai1 ,
HAN Qi1 ,
FENG Dongfang1 ,
DENG Yan1 ,
YIN Zuoming1

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1. General Hospital of Tibet Military Area Command of PLA, Lhasa 850007, Tibet Autonomous Region, China; 2. Chengdu Western Hospital, Chengdu 610036, Sichuan Province, China; 3. General Hospital of Western Theater Command of PLA, Chengdu 610083, Sichuan Province, China

Received date: 2022-08-24

Online published: 2023-02-25

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Abstract

Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is the causative agent of the coronavirus disease 2019(COVID-19), which spreads rapidly in humans and endangers global health and economy. There are no specific and effective antiviral drugs for the treatment of COVID-19 currently. To infect host cells successfully for a virus, receptor binding and virus internalization are considered to be the initial steps. A key to combat SARS-CoV-2 infection is to investigate the viral receptors, which determine its infectivity and host range. The discovery and identification of cell receptors for SARS-CoV-2 will provide new therapeutic targets for COVID-19. This article reviews the recent findings on the entry and attachment receptors for SARS-CoV-2.

Key words： Severe acute respiratory syndrome coronavirus 2; Entry; Receptor; Attachment receptor; Spike; Receptor-binding domain

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CHEN Shenglin1* , XIAO Man2* , LI Zhaozhong3 , XU Zhikai1 , HAN Qi1 , FENG Dongfang1 , DENG Yan1 , YIN Zuoming1 . Recent progress on cell receptors for SARS-CoV-2[J]. Journal of Microbes and Infections, 2023 , 18(1) : 46 -54 . DOI: 10.3969/j.issn.1673-6184.2023.01.006

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