微生物与感染
2025年1月8日 星期三   首页 |  主编心语 |  期刊介绍 |  编委阵容 |  投稿指南 |  出版道德 |  期刊订阅 |  联系我们 | English
微生物与感染
  综述 本期目录 | 过刊浏览 | 高级检索 |
斑马鱼用于病原菌感染与免疫及自噬的研究进展
李金玲,吴淑燕,黄瑞
苏州大学基础医学与生物科学学院病原生物学系,苏州 215123
Advances on zebrafish to invesgate pathogen infection and immunity as well as autophagy
LI Jin-Ling, WU Shu-Yan, HUANG Rui
Department of Microbiology, Medical College of Soochow University, Suzhou 215123, China
全文: PDF (694 KB)   HTML (0)
输出: BibTeX | EndNote (RIS)      
摘要: 斑马鱼作为一种脊椎动物模型,是研究病原菌感染与免疫的理想对象,目前已成功构建了多种细菌感染斑马鱼模型。由于其在通体透明的幼鱼阶段只有天然免疫系统发育完善,因此利用斑马鱼研究天然免疫具有许多优势,且能避免获得性免疫的干扰。自噬作为一种高度保守的胞内降解过程,是天然免疫的重要部分,可通过Toll样受体或黏膜免疫系统等参与对细菌的应答。目前对斑马鱼自身发育需要及清除母体残留物所进行的自噬已进行了初步研究,最近细菌感染斑马鱼的体内自噬研究模型已成功构建,这对体内异源自噬机制的研究意义重大。本文就近年来利用斑马鱼模型研究病原菌感染与免疫及自噬的进展作一综述。

服务
把本文推荐给朋友
加入我的书架
加入引用管理器
E-mail Alert
RSS
作者相关文章
李金玲
吴淑燕
黄瑞
关键词 斑马鱼病原菌感染与免疫自噬    
Abstract:As a well-known biological vertebrate model, zebrafish is an ideal object to study pathogen infection and immunity. Many bacteria-zebrafish infection models have been constructed successfully. On its translucent larval stage, only innate immune system has developed perfectly. So using zebrafish to study innate immunity has many advantages and can avoid the interference of adaptive immunity. As a highly conservative intracellular degradation process, autophagy is an important event of innate immunity. It can initiate a response against bacteria through Toll-like receptors or mucosal immune system. A preliminary study on autophagy of zebrafish associated with its development and eliminating maternal residues has been going on. And now a new bacteria-zebrafish model for studying autophagy has been constructed successfully, which is of great significance to research the mechanisms of xenophagy. Here we summarize the results gained from zebrafish on pathogen infection and immunity as well as autophagy in recent years.

Key wordsZebrafish    Pathogen infection and immunity    Autophagy
通讯作者: 黄瑞   
引用本文:   
李金玲,吴淑燕,黄瑞. 斑马鱼用于病原菌感染与免疫及自噬的研究进展[J]. 微生物与感染, 2014, 9(1): 48-53.
LI Jin-Ling, WU Shu-Yan, HUANG Rui. Advances on zebrafish to invesgate pathogen infection and immunity as well as autophagy. JOURNAL OF MICROBES AND INFECTIONS, 2014, 9(1): 48-53.
链接本文:  
http://jmi.fudan.edu.cn/CN/      或     http://jmi.fudan.edu.cn/CN/Y2014/V9/I1/48

版权所有 © 2008 《微生物与感染》编辑部
地址:上海市医学院路138号 邮编:200032
Tel:021-54237633 Fax:021-64434224    E-mail:jmi@fudan.edu.cn
本系统由北京玛格泰克科技发展有限公司设计开发  技术支持:support@magtech.com.cn