自噬在细菌感染与免疫应答中的作用

李琼; 吴淑燕; 黄瑞

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微生物与感染 ›› 2009, Vol. 4 ›› Issue (2) : 108-111.

综述

自噬在细菌感染与免疫应答中的作用

李琼；吴淑燕；黄瑞

作者信息 +

Role of autophagy in bacterial infections and immune responses

LI Qiong；WU Shu-Yan；HUANG Rui

Author information +

文章历史 +

摘要

自噬是调节细胞生长、发育的一种重要的程序性细胞死亡方式,其作用是一把“双刃剑”:一方面,它可清除病原体,保护机体免受损害;另一方面,有些细菌在进化中形成了独特机制,通过干扰或阻止自噬溶酶体形成等来调控或阻碍自噬,从而利于自身的复制和存活。自噬是天然免疫的重要部分,可通过Toll样受体或黏膜免疫系统等参与对细菌及毒素的应答;细胞免疫的效应细胞可通过分泌细胞因子调节自噬,进而调控获得性免疫应答。在抗胞内菌感染时,自噬在调节Th1/Th2细胞的免疫偏移方面也起关键作用。

Abstract

Autophagy is an important form of programmed cell death that regulates the growth and development of cells. It acts as a ‘two-edge sword’. On one side, autophagy eliminates microbes; on the other, many bacteria have developed distinct mechanisms to regulate and interfere with autophagy for their own replication and survival. Autophagy is an important event in the innate immune response. It can initiate a response to bacteria and bacterial toxins through Toll-like receptor mechanisms or mucosal immune system. Effector cells of the cellular immune system can regulate autophagy by secreting different cytokines, allowing the organism to re-tune its adaptive immune response. Autophagy may play a pivotal role in regulating the immune polarization of Th1/Th2 in fighting intracellular bacteria.

导出引用

李琼；吴淑燕；黄瑞. 自噬在细菌感染与免疫应答中的作用[J]. 微生物与感染. 2009, 4(2): 108-111

LI Qiong；WU Shu-Yan；HUANG Rui. Role of autophagy in bacterial infections and immune responses[J]. Journal of Microbes and Infections. 2009, 4(2): 108-111