侵入宿主后，细菌生长、繁殖并与宿主相互作用，引发机体不同程度的病理变化。为抑制细菌致病过程，宿主免疫系统产生抗感染免疫应答，感染的发生和发展取决于细菌对机体的致病性与机体抗细菌免疫的相互抗争。在细菌所致感染性疾病的发生、发展过程中，细菌与宿主细胞的拮抗往往涉及程序性细胞死亡(programmed cell death, PCD)这一过程。新近发现Gasdermin家族成员Gasdermin D和Gasdermin E参与PCD过程，并在其中发挥重要作用，跟踪其研究进展将有助于应对细菌感染造成的威胁。

Bacteria can grow and multiply inside the host after invasion, causing pathological changes. In order to inhibit the pathogenic process of bacteria, the host immune system produces anti-infective responses. The occurrence and development of infection depends on the interaction between pathogenicity of bacteria and antimicrobial immunity of host. Programmed cell death (PCD) is usually involved in the confrontation between bacteria and host cells in bacteria-induced infectious diseases. It has been discovered that members of the Gasdermin (GSDM) family such as GSDMD and GSDME participate in the PCD process and play an important role in it. Tracking the research progress can help us to deal with the threat posed by bacterial infection.