Abstract：Bacterial brain abscess refers to a focal, intracerebral infection that begins as a localized area of cerebritis and develops into a collection of pus caused by bacteria. Though the attack rate is rather low, it may lead to severe consequences, even lethal. In terms of etiology, there is a correlation between predisposing factors in patients and pathogens that cause the infection, among which, Streptococcus and Staphylococcus are the most common. In China, so as in Asia, Gram-negative bacilli also make a large part. In clinical practice, the combination of the third generation of cephalosporins and metronidazole, which covers the majority of bacteria that cause brain abscess, is the most commonly used empirical regimen. Basically, the treatment of bacterial brain abscess lasts more than 6 weeks, and it is strongly recommended that patients’ clinical manifestations and brain imaging be closely monitored during the treatment. Currently, surgery combined with medical treatment, is the major therapy of brain abscess, which may reduce the duration of treatment. Conservative treatment can be adoptable under some circumstances, such as when the size of abscess is small, and condition of the patient is relatively good, etc., so that risks of invasive operation could be avoided. Unfortunately, till nowadays, there is insufficient evidence about medical treatment of bacterial brain abscess in many aspects.
钱奕亦，金嘉琳，张文宏. 细菌性脑脓肿的抗感染治疗进展[J]. 微生物与感染, 2018, 13(1): 49-55.
QIAN Yiyi, JIN Jialin, ZHANG Wenhong. Progress in medical treatment of bacterial brain abscess. JOURNAL OF MICROBES AND INFECTIONS, 2018, 13(1): 49-55.
2018, Vol. 13 
