Abstract:New pathogens have truly emerged with the globalization of travel and trade, changes in demographics and land use, susceptibility to opportunistic organisms associated with immunosuppression, and climate change. The so-called new pathogens can be divided into three categories, the pathogen identified first time in a region or a country, the mutated pathogens with increased virulence and/or infectivity which could not be correctly identified by current methods, and the pathogen emerged for the first time worldwide. The new pathogen in term of a subject should include the basic research, development of technology and strategies to establish the technology and scientific system to define a causal relationship between agent and disease, to understand how it causes disease and to assess the potential threat to public. The subject of new pathogen should interact with many disciplines such as genomics, epidemiology, clinical medicine, computational biology, ecology, animal sciences and others. The new molecular technologies such as microbial microarrays and unbiased high throughput sequencing have enabled efficient microbial surveillance and discovery. The aim of new pathogen study is to improve our ability and capacity to identify, to study, to control the new pathogens with public health significance. With development and progress of theory and methodology, we should be able to correctly identify the pathogen emerged for first time in China, to correctly and timely identify the mutated pathogen with significant public health significance, and to timely find the pathogen emerged for first time in the world.
通讯作者:
徐建国
E-mail: xujianguo@icdc.cn
引用本文:
徐建国. 发现新病原、建立新病原学的技术与理论体系[J]. 微生物与感染
, 2010, 5(3): 129-134.
Jian-Guo Xu. Discovery of New Pathogen and associated technology and basic theory. Journal of Microbes and Infections, 2010, 5(3): 129-134.