
人类免疫缺陷病毒与深部真菌感染
Human immunodeficiency virus and deep fungal infection
人类免疫缺陷病毒(HIV)感染的发病率与致死率很高,已成为人类健康的一大威胁,其中约50%的HIV感染者最终因侵袭性真菌病而死亡。高效抗反转录病毒治疗(HAART)的应用大大降低了HIV感染者深部真菌病的发生率。因此,深入研究HIV与深部真菌病的关系,对预防、诊断和治疗HIV感染者深部真菌病具有十分重要的意义。本文归纳了HIV感染者深部真菌病的流行病学调查、诊断与治疗进展,有助于临床医师预防和诊治HIV感染者深部真菌病,也为将来新型抗真菌药物的研发提供了思路和方向。
Human immunodeficiency virus (HIV) is a global threat to health with high morbidity and mortality, and 50% of all HIV-related death is associated with invasive fungal infection. Highly active antiretroviral therapy (HAART) is used to treat HIV infection and can significantly reduce incidence of HIV-related opportunistic fungal infection. In this article, the epidemiology, diagnosis and treatment of HIV-related fungal infection are reviewed, giving an insight into study of deep fungal infection and a reference for clinic practice.
人类免疫缺陷病毒 / 深部真菌病 / 流行病学 / 抗真菌药物
Human immunodeficiency virus / Deep fungal infection / Epidemiology / Antifungal drug
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国家重点基础研究发展计划(2013CB531601-06),国家“十二五”科技重大专项(2013ZX10004612-001),上海市科委重点实验室建设项目(14DZ2272900)
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