外泌体在人类免疫缺陷病毒1型感染中的研究进展

邱勇1; 2; 马晶2; 曾毅1; 2

doi:10.3969/j.issn.1673-6184.2018.03.006

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微生物与感染 ›› 2018, Vol. 13 ›› Issue (3) : 171-178. DOI: 10.3969/j.issn.1673-6184.2018.03.006

综述

外泌体在人类免疫缺陷病毒1型感染中的研究进展

邱勇^1,2，马晶²，曾毅^1,2

作者信息 +

Research advances in exosomes in human immunodeficiency virus type 1 infection

QIU Yong^1,2, MA Jing², ZENG Yi^1,2

Author information +

文章历史 +

摘要

外泌体(exosome)是动物细胞在生理或病理条件下分泌到胞外的内生性纳米微囊，在疾病发生机制和药物运输载体等研究领域成为新宠。近年来发现，外泌体在人类免疫缺陷病毒1型(human immunodeficiency virus type 1，HIV-1)感染者体内能转移病毒组分和病毒相关免疫分子，与HIV-1感染密切相关。本文以外泌体介导的HIV-1感染机制为重点，围绕外泌体与HIV-1感染的关系进行综述。

Abstract

Exosomes are endogenous nanoparticles secreted by cells in physiological or pathological state. It is a durably hot topic in research fields of pathology and drug carrier systems. In recent years, it has been found that exosomes can transfer viral components and virus-related immune molecules in human immunodeficiency virus type 1 (HIV-1) infection. The mechanisms of exosome-mediated HIV-1 infection are reviewed in the present paper.

导出引用

邱勇1,2，马晶2，曾毅1,2. 外泌体在人类免疫缺陷病毒1型感染中的研究进展[J]. 微生物与感染. 2018, 13(3): 171-178 https://doi.org/10.3969/j.issn.1673-6184.2018.03.006

QIU Yong1,2, MA Jing2, ZENG Yi1,2. Research advances in exosomes in human immunodeficiency virus type 1 infection[J]. Journal of Microbes and Infections. 2018, 13(3): 171-178 https://doi.org/10.3969/j.issn.1673-6184.2018.03.006