Abstract:In order to investigate the epidemic of hepatitis E virus (HEV) in human immunodeficiency virus (HIV)-infected patients,235 serum samples collected from HIV-infected patients were subjected to molecular detections for HEV infection, these including enzyme-linked immunosorbent assay (ELISA) for HEV IgG and IgM and antigen, and polymerase chain reaction (PCR) method for HEV RNA. Roche COBAS®AmpliPrep/COBAS®TaqMan HIV-1 Test was applied for HIV levels. No HEV RNA-positive results were found in this study. The positive rate of HEV IgG antibody in intravenous drug users, blood component donors and unexplained HIV infection population were 49.3%, 39.5% and 30.4%, respectively, and the collective positive rate in HIV-infected patients was 37.4%. There was no statistically significant difference (χ2=2.978, P>0.05) in HIV viral load among three HIV-infected groups, and between HEV IgG-positive and -negative populations (P>0.05). The results suggest that more studies are required to elucidate the role of HEV infection in HIV patients, and to establish effective preventive measures, including vaccine inoculation for HIV-infected patients.
黄维金,宋爱京,许四宏,聂建辉,刘强,赵晨燕,张黎,王佑春. 不同人类免疫缺陷病毒感染途径群体中戊型肝炎病毒的流行情况[J]. 微生物与感染, 2016, 11(4): 212-216.
HUANG Weijin, SONG Aijing, XU Sihong, NIE Jianhui, LIU Qiang, ZHAO Chenyan, ZHANG Li, WANG Youchun. A serological study of hepatitis E virus infection in different human immunodeficiency virus-infected groups. JOURNAL OF MICROBES AND INFECTIONS, 2016, 11(4): 212-216.