Abstract：The overexpression of efflux pump is one of the most important multidrug-resistant mechanisms in Acinetobacter baumannii (A. baumannii). The understanding of their complicated mechanisms will help to find out efficient coping strategy. So far four prominent families of efflux transporters in A. baumannii have been reported, including resistance-nodulation-cell division (RND) superfamily, major facilitator superfamily (MFS), multidrug and toxic compound extrusion (MATE) superfamily, and small multidrug resistance (SMR) superfamily. They can be divided into chromosomally encoded efflux system and acquired efflux system. The substrates are also distinguished among different efflux transporters. In this review, the classification, function and regulation of efflux pumps in A. baumannii are described.
王鹏，奚敏，余永胜，臧国庆，汤正好. 鲍曼不动杆菌中外排泵介导耐药机制的研究进展[J]. 微生物与感染, 2016, 11(5): 297-301.
WANG Peng, XI Min, YU Yongsheng, ZANG Guoqing, TANG Zhenghao. Research advance in efflux-mediated antibiotic resistance of Acinetobacter baumannii. JOURNAL OF MICROBES AND INFECTIONS, 2016, 11(5): 297-301.
2016, Vol. 11 
