Drug resistance of Acinetobacter baumannii isolated from long-term hospitalized elderly patients
ZHAO Fu-Ju1, FANG Yi1, LIU Hua-Yong2, Zhou Li-Fang1, PANG Li-Feng1, Liu Wen-Jian1, ZHAO Hu1
1. Department of Clinical Laboratory, Huadong Hospital, Fudan University, Shanghai 200040, China; 2. Key Laboratory of Medical Molecular Virology of Ministries of Education and Health Shanghai Medical College, Fudan University, Shanhai 200032, China
Abstract：To investigate the drug resistance of Acinetobacter baumannii (A. baumannii) isolated from long-term hospitalized elderly patients in our hospital. A total of 52 isolates of A. baumannii were isolated from September, 2011 to August 2012 from elderly nosocomial patients in our hospital. The types of enzyme production, biofilm-forming ability, drug resistance and carrying resistance genes were tested. The infection of A. baumannii most frequently occurred in respiratory intensive care unit. The main separation sampling was sputum specimens (86.54%)．The multi-drug resistant A. baumannii strains were identified mostly (76.92%). A. baumannii isolates showed the lowest resistant rate to cefoperazone-sulbactam, which was 30.77%. The resistant rates to other antimicrobial agents were over 50%. The positive rate of enzyme production was 82.69%, and the most common production was other hydrolytic enzymes (63.46%). The biofilm-forming strains accounted for 5.77% of the isolates. 9 kinds of resistance genes were found in these 6 extensively drug-resistant strains. The study indicates that the grim situation of drug resistance of A. baumannii isolated from long-term hospitalized elderly patients. It is necessary to strengthen the monitoring of drug resistance, especially in respiratory intensive care unit. Meanwhile, drug resistance surveillance and disinfection and isolation should be strengthened in the endemic areas from where the biofilm-positive strains were isolated, so as to prevent and control the production and spread of multi-drug resistant and extensively drug resistant bacteria.
赵付菊1，方毅1，刘华勇2，周丽芳1，庞立峰1，刘文健1，赵虎1. 长期住院老年患者感染的鲍曼不动杆菌耐药性分析[J]. 微生物与感染, 2014, 9(3): 167-173.
ZHAO Fu-Ju1, FANG Yi1, LIU Hua-Yong2, Zhou Li-Fang1, PANG Li-Feng1, Liu Wen-Jian1, ZHAO Hu1.. Drug resistance of Acinetobacter baumannii isolated from long-term hospitalized elderly patients. JOURNAL OF MICROBES AND INFECTIONS, 2014, 9(3): 167-173.
