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Interferon α and ribavirin on hepatitis C virus replication |
YANG Meng1; HE Sheng-Fei2; REN Hao2; ZHAO Lan-Juan2; QI Zhong-Tian2 |
1. No. 10 Cadets Company, Graduate Administration Division, Second Military Medical University,Shanghai 200433, China;2. Department of Microbiology, Shanghai Key Laboratory of Medical Biodefense, Second Military Medical University, Shanghai 200433, China |
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Abstract The current standard therapy for hepatitis C virus (HCV) infection consists of a combination of interferon α(IFN-α) and ribavirin. In this study, the effects of IFN-α and ribavirin on HCV replication as well as antiviral genes were examined. The results showed that 100 u/ml IFN-α significantly reduced HCV RNA levels. Ribavirin inhibited HCV replication in a dose-dependent manner and ribavirin in combination with IFN-α exhibited synergetic inhibitory effect on HCV replication, and NS3 and E2 protein expression. IFN-α increased the levels of IFN regulatory factor 9 (IRF9) and IFN-stimulated gene 15 (ISG15) in a dose-dependent manner. However, 1 and 5 μg/ml ribavirin had no such effects on the IRF9 and ISG15 induction.
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Received: 12 December 2011
Published: 01 January 2012
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Corresponding Authors:
QI Zhong-Tian
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