Methicillin-resistant Staphylococcus aureus (MRSA) rarely causes enteritis, and MRSA enteritis is generally more common in patients with long-term antibiotic use and gastrointestinal surgery. In this case, the child had no history of long-term medication and surgery, and suddenly developed fever, vomiting, shifting right lower abdominal pain. Appendicitis was suspected at the beginning, but no imaging signs of appendicitis were found on the abdominal computed tomography (CT), with abnormally dilated intestinal tube and fecal retention, and a large amount of dark green watery stool was drained through the canal. After etiological tests of throat swab and fecal specimens, the child was diagnosed with MRSA enteritis. After oral administration of vancomycin and symptomatic treatment, the child recovered and was discharged from hospital. This case and MRSA enteritis-related literatures were reviewed to conduct an in-depth analysis of the pathogenesis, clinical manifestations, treatment plan of MRSA enteritis, so as to provide new ideas for the standardized diagnosis and treatment of MRSA enteritis.