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| Research progress on the immune function changes of B lymphocytes induced by severe fever with thrombocytopenia syndrome virus infection |
| LI Xue1，2，*, XU Wen2，*, CHEN Weiwei2 |
| 1. School of Pharmaceutical Sciences, Binzhou Medical, Yantai 264003, Shandong Province, China; 2. Institute of Infectious Disease Medicine, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China |
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Abstract Sever fever with thrombocytopenia syndrome virus (SFTSV) is a novel virus discovered in recent years. Sever fever with thrombocytopenia syndrome (SFTS) is caused by SFTSV infection, characterized by high fever, thrombocytopenia, leukopenia and multiple organ function damage, with a mortality rate from 5% to 30%. There is no proven effective antiviral drugs and vaccine available now. SFTSV infection can cause immune dysfunction in patients, and B lymphocytes are one of the important target cells for SFTSV infection, but the impact of SFTSV infection on B lymphocyte function is still unclear. This article reviews research on the abnormalities and underlying mechanism of B lymphocyte functions caused by SFTSV infection, so as to promote the research progress of the immunopathological mechanism of SFTSV infection, providing a basis for a deeper understanding of the impact of SFTSV infection on B lymphocytes and the development of related diagnostic and therapeutic technologies.
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Received: 07 July 2023
Published: 25 December 2023
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Corresponding Authors:
CHEN Weiwei
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2023, Vol. 18 
