|
|
|
| Advances in studies on the role of NLRP 6 in host immunity against bacterial infection |
| CAO Yu1, 2, GONG Yating1, WU Shuyan1, HUANG Rui1 |
| 1. School of Biology & Basic Medical Science, Suzhou Medical College of Soochow University, Suzhou 215123, Jiangsu Province, China; 2. Laboratory Department, Children’s Hospital of Soochow University, Suzhou 215025, Jiangsu Province, China |
|
|
|
| Guide |
|
|
Abstract Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6 (NLRP 6) is one of the important intracellular pattern recognition receptors of host innate immunity and is involved in the regulation of infection, inflammation, tumor and metabolic diseases. By sensing pathogenic organisms such as bacteria, viruses, fungi, parasites and their products, such as lipoteichoic acid (LTA) of Gram-positive bacterium and viral double-stranded RNA, it can regulate the anti-infection immune effect of the body, weaken or enhance the host resistance and affect the outcome of infection. This article reviews the structure and function of NLRP 6 and its role in host immunity against bacterial infection.
|
|
Received: 15 September 2023
Published: 25 December 2023
|
|
|
| Fund: |
|
Corresponding Authors:
HUANG Rui
|
|
|
|
|
|
|
2023, Vol. 18 
