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| Mechanism of interferon-γ-mediated anti-Chlamydia infection |
| TANG Guo-Fang；LI Zhong-Yu；WU Yi-Mou |
| Institute of Pathogenic Biology Institute, School of Medicine, University of South China, Hengyang 421001, China |
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Abstract Chlamydia is an intracellular bacterium that infects many vertebrates, including humans. Previous studies have shown that interferon-γ(IFN-γ) plays an important role in defense against Chlamydia infection. IFN-γ-mediated anti-Chlamydia effector mechanisms may include the exhaustion of tryptophan, the induction of iron loss, and/or the activation of inducible nitric oxide synthase (iNOS). However, Chlamydia has evolved to develop mechanisms to escape IFN-γ functions. In this review, we will discuss IFN-γ-mediated effector mechanisms in the control of Chlamydia infection.
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Received: 01 January 1900
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Corresponding Authors:
WU Yi-Mou
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MA Xi1,2, TANG Kejun3, DU Yushen2,3, SUN Ren2,3. Precision-designed vaccine[J]. JOURNAL OF MICROBES AND INFECTIONS, 2018, 13(5): 257-264. |
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