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| Precision-designed vaccine |
| MA Xi1,2, TANG Kejun3, DU Yushen2,3, SUN Ren2,3 |
| 1. Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; 2. Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; 3. Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China |
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Abstract The introduction of vaccines has greatly reduced the rates of morbidity and mortality caused by infectious diseases, and has a transformational effect on global human health. Here, we systematically review the history and development of vaccines, and analyze the advantages and drawbacks of different types of vaccines. Moreover, we detail a broadly protective vaccine type, which we dub precision-designed vaccine. Precision-designed vaccine is a high-throughput and reverse genetics based recombinant vaccine, which is precisely designed on a comprehensive functional characterization of a pathogen genome. Precision medicine, which takes into account individual variability in genes, environment, and lifestyle, leads to a new revolution in healthcare system. In like manner, the emerging precision-designed vaccine, targetting specific genes, proteins and pathways of pathogens or abnormal cells, sheds new light on the design of vaccines and can help usher in a new era of vaccinology.
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Received: 17 September 2018
Published: 25 October 2018
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Corresponding Authors:
DU Yushen, SUN Ren
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2018, Vol. 13 
