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A minireview on necroptosis and related signaling pathways |
YU Xin1, CHEN Li-Xiang1, ZHOU Xiao-Hui1,2 |
1. Shanghai Public Health Clinical CenterAffiliated to Fudan University, Shanghai 201508, China; 2. Key Laboratory of Medical Molecular Virology of Ministries of Education and Health, Basic Medical Sciences, Fudan University, Shanghai 200032, China |
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Abstract
It was believed that apoptosis was the only programmed cell death in the development and homeostasis of vertebrate. Meanwhile, necrosis was considered to be unprogrammed. However, growing evidences have demonstrated that some types of necrosis can also be regulated by signaling molecules, and these types of necrosis could be defined as programmed necrosis or necroptosis. In this review, the morphological characteristics of necroptosis, and the relationships between necroptotic signaling pathway and the immune system’s function and inflammatory response are summarized.
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Received: 20 May 2014
Published: 25 February 2015
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Corresponding Authors:
ZHOU Xiao-Hui
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