Bacteria can grow and multiply inside the host after invasion, causing pathological changes. In order to inhibit the pathogenic process of bacteria, the host immune system produces anti-infective responses. The occurrence and development of infection depends on the interaction between pathogenicity of bacteria and antimicrobial immunity of host. Programmed cell death (PCD) is usually involved in the confrontation between bacteria and host cells in bacteria-induced infectious diseases. It has been discovered that members of the Gasdermin (GSDM) family such as GSDMD and GSDME participate in the PCD process and play an important role in it. Tracking the research progress can help us to deal with the threat posed by bacterial infection.