微生物与感染
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JOURNAL OF MICROBES AND INFECTIONS  2019, Vol. 14 Issue (6): 363-370    DOI: 10.3969/j.issn.1673-6184.2019.06.008
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Advances in the study of bacterial infection and programmed host cell death mediated by Gasdermin family
WU Chaoyi, ZHOU Liting, HUANG Rui, WU Shuyan
School of Biology & Basic Medical Science, Medical College of Soochow University, Suzhou 215123, China

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Abstract  Bacteria can grow and multiply inside the host after invasion, causing pathological changes. In order to inhibit the pathogenic process of bacteria, the host immune system produces anti-infective responses. The occurrence and development of infection depends on the interaction between pathogenicity of bacteria and antimicrobial immunity of host. Programmed cell death (PCD) is usually involved in the confrontation between bacteria and host cells in bacteria-induced infectious diseases. It has been discovered that members of the Gasdermin (GSDM) family such as GSDMD and GSDME participate in the PCD process and play an important role in it. Tracking the research progress can help us to deal with the threat posed by bacterial infection.
Key wordsBacterial infection      Gasdermin (GSDM) family      Programmed cell death     
Received: 24 July 2019      Published: 25 December 2019
Corresponding Authors: WU Shuyan   
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WU Chaoyi,ZHOU Liting,HUANG Rui等. Advances in the study of bacterial infection and programmed host cell death mediated by Gasdermin family[J]. JOURNAL OF MICROBES AND INFECTIONS, 2019, 14(6): 363-370.
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http://jmi.fudan.edu.cn/EN/10.3969/j.issn.1673-6184.2019.06.008     OR     http://jmi.fudan.edu.cn/EN/Y2019/V14/I6/363
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