The plague, caused by Yersinia pestis, has caused three world-wide disasters to human beings and hundreds of millions of people’s death historically. As one of the most serious severe infectious diseases, the prevention and control of plague in China is particularly important. In China, prevention and control of plague have been carried out intensively by the government , including promoting epidemiological investigations and formulating various prevention and control measures. The fierce momentum of the plague epidemic nationwide had been curbed in a short period, nevertheless, the plague epidemic had never been eliminated and still had been broken out in western China because of the presence of the host of Yersinia pestis. Based on the epidemic situation of plague, we summarized prevention and control mode of plague in Qinghai province . In this article, we introduce the “Qinghai Model” for plague preventing and controlling, specifically including way of working, platform constructing, public educating, investigating and monitoring, staff training, eliminating of hidden danger, and ecological civilization constructing etc.. It has effectively controlled plague prevalence in Qinghai. Itwill provide new strategy for the development and countermeasures of plague prevention and control in Qinghai province.