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Research of hepatitis B virus core protein’s allosteric modulators |
CHEN Shiqi, MAO Richeng, ZHANG Jiming |
Department of Infectious Diseases, Huashan Hospital, Fudan University, Shanghai 200040, China |
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Abstract Chronic hepatitis B virus infection is difficult to cure due to the persistence of covalently closed circular DNA and viral-mediated inactivation of host immune responses. Existing nucleoside (acid) analogs or pegylated interferon therapy are difficult to achieve a high ratio of HBV surface antigen clearance. This article reviews the structure and function of HBV core protein, the classification and application prospects of core protein allosteric modulators.
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Received: 17 September 2019
Published: 25 October 2020
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Corresponding Authors:
ZHANG Jiming, MAO Richeng
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