Abstract:The objective of the current study is to evaluate sera lipoarabinomannan-38kD-IgG (LAM-38kD-IgG) test in the serological diagnosis of tuberculosis(TB). 128 active tuberculosis patients (107 pulmonary TB, 21 extrapulmonary TB ),51 with latent TB infection and 68 healthy people were enrolled and diagnosed by clinic, bacteriology and X-ray examination. All specimens were studied for LAM-38kD-IgG by using Enzyme-Linked Immunosorbent Assay(ELISA). The results demonstrated that the total sensitivity and specificity of LAM-38kD-IgG test of active tuberculosis patients were 46.88% and 98.53%. The positive predict value and the negative predict value of LAM-38kD-IgG test were 98.36% and 49.63% respectively. The sensitivity of LAM-38kD-IgG test in the diagnosis of pulmonary tuberculosis and extra-pulmonary tuberculosis were 46.73% and 47.62% (P>0.05) respectively; the sensitivities in the patients with smear-positive and smear-negative pulmonary tuberculosis were 52.54% and 39.58% (P>0.05) respectively. The specificity of LAM-38kD-IgG test was higher than tuberculin test (TST) (41.46%). It was concluded that LAM-38kD-IgG test has a very good specificity and an acceptable sensitivity and positive predictive value. It is thought that it could be used in combination with other methods to increase diagnostic accuracy, especially for culture-negative and extrapulmonary tuberculosis cases, which are difficult to diagnose.
王森; 陈嘉臻; 张文宏. 脂阿拉伯甘露糖联合38kD蛋白在结核病诊断中的应用[J]. 微生物与感染
, 2010, 5(2): 68-72.
WANG Sen; CHEN Jia-Zhen; ZHANG Wen-Hong. Evaluation of lipoarabinomannan-38kD-IgG test in clinical diagnosis of tuberculosis. Journal of Microbes and Infections, 2010, 5(2): 68-72.