Biological characteristics related to the transmission of enterovirus 71 in neonatal rhesus monkeys
WANG Jing-Jing1,2; LI Wei1; ZHAO Hong-Ling1; LIU Long-Ding1; TANG Dong-Hong1; YANG Li-Xian1; DONG Cheng-Hong1; NA Rui-Xiong1; WANG Li-Chun1; ZHANG Ying1; LIANG Yan1; LIAO Yun1; LI Qi-Han1
1. Institute of Medical Biology, Chinese Academy of Medicine Science and Peking Union Medical College; Yunnan Key Laboratory of Vaccine Research & Development on Severe Infectious Disease, Kunming 650118, China; 2. Kunming Medical University, Kunming 650032, China
Abstract：Using an established animal model of enterovirus 71 (EV71) infection, the risk of EV71 transmission from infected neonatal to uninfected rhesus monkeys was assessed. Two 1-2 month-old neonatal monkeys were infected with EV71 via nasal spray (Group A). At 7 days post-infection , two neonatal monkeys assigned to Group B were inoculated with extracts from the feces of monkeys from Group A, via the same route. Meanwhile, two neonatal monkeys were inoculated with fecal extracts via intravenous injection (control group). The mothers of Group B were also enrolled as Group C. Maternal and infant data including clinical symptoms, viral load monitoring, and neutralizing antibody titers were obtained every day post-infection. The results from virological and pathological analysis showed that the transmission of EV71 could be observed in the neonatal monkey model. These findings also showed that the transmission of EV71 was more likely via re叩iratory route and that infection could be passed from infant to mother. These results provide additional information on the search for factors related to EV71 infection in childhood.
王晶晶1,2; 李薇1; 赵红玲1; 刘龙丁1; 唐东红1; 杨丽仙1; 董承红1; 纳锐雄1; 王丽春1; 张莹1; 梁燕1; 廖芸1; 李琦涵1. 利用恒河婴猴模型对肠道病毒71型传播感染特征的生物学分析[J]. 微生物与感染
, 2011, 6(3): 133-138.
WANG Jing-Jing1,2; LI Wei1; ZHAO Hong-Ling1; LIU Long-Ding1; TANG Dong-Hong1; YANG Li-Xian1; DONG Cheng-Hong1; NA Rui-Xiong1; WANG Li-Chun1; ZHANG Ying1; LIANG Yan1; LIAO Yun1; LI Qi-Han1. Biological characteristics related to the transmission of enterovirus 71 in neonatal rhesus monkeys. Journal of Microbes and Infections, 2011, 6(3): 133-138.
