1. Division of Hepatobiliary and Pancreatic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; 2. Department of Molecular and Medical Pharmacology, University of California, Los Angeles, CA 90095, USA; 3. Cancer Institute (Key Laboratory of Cancer Prevention and Intervention, China National Ministry of Education, Key Laboratory of Molecular Biology in Medical Sciences, Zhejiang Province, China), The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
Abstract：The introduction of vaccines has greatly reduced the rates of morbidity and mortality caused by infectious diseases, and has a transformational effect on global human health. Here, we systematically review the history and development of vaccines, and analyze the advantages and drawbacks of different types of vaccines. Moreover, we detail a broadly protective vaccine type, which we dub precision-designed vaccine. Precision-designed vaccine is a high-throughput and reverse genetics based recombinant vaccine, which is precisely designed on a comprehensive functional characterization of a pathogen genome. Precision medicine, which takes into account individual variability in genes, environment, and lifestyle, leads to a new revolution in healthcare system. In like manner, the emerging precision-designed vaccine, targetting specific genes, proteins and pathways of pathogens or abnormal cells, sheds new light on the design of vaccines and can help usher in a new era of vaccinology.
马玺1,2，汤可骏3，杜雨棽2,3，孙仁2,3. 精准设计疫苗[J]. 微生物与感染, 2018, 13(5): 257-264.
MA Xi1,2, TANG Kejun3, DU Yushen2,3, SUN Ren2,3. Precision-designed vaccine. JOURNAL OF MICROBES AND INFECTIONS, 2018, 13(5): 257-264.
2018, Vol. 13 
