由于抗菌药物的开发周期越来越长，远远赶不上细菌耐药的发展速度，临床鲍曼不动杆菌多重耐药与泛耐药现象日益严重。因此，人们越来越关注对抗菌药物以外的抗菌物质的开发，尤其是从生存条件方面来研究抑制耐药菌活性的方法，如金、银、铜等金属离子对鲍曼不动杆菌的作用。本文主要综述铁、锌等金属离子及其螯合物对鲍曼不动杆菌的抗菌作用。铁、锌等金属离子通过与一系列酶的协同作用，调控外排泵或影响生物膜形成及其黏附性等来抑制细菌生长。此外，一些非必需金属如金、银、钯等对鲍曼不动杆菌也具有很强的毒性，有良好的抗菌和降低耐药率的效果，可作为医疗留置器械的抗菌涂层等来预防感染。

Because the pace of new antibiotic development could not match the development of bacterial drug resistance, the phenomenon of multidrug-resistance and pan-resistance of Acinetobacter baumannii (A. baumannii) in clinical treatment is becoming widespread. Therefore, more and more attentions have been paid to the development of antimicrobial substances other than classical antimicrobial agents, such as metal ions and chelates. The antimicrobial activity of iron and zinc against A. baumannii was reviewed in this paper. Iron, zinc and the other essential metal ions can inhibit bacterial growth by regulating efflux pumps or affecting biofilm formation and adhesion. In addition, metals such as gold, silver and palladium, also have strong antibacterial effects and can be used as antimicrobial coating for medical indwelling devices to prevent infections.