本研究旨在研究疫情期间三色分区管理模式在院内严重急性呼吸系统综合征冠状病毒2型(SARS-CoV-2，以下简称新冠病毒)核酸采集管理上的应用效果。选取2022年4月1—15日于我院进行新冠病毒核酸采样的患者和工作人员作为对照组，采用原核酸采样检测模式；选取2022年4月16日—30日我院进行新冠病毒核酸采样的患者和工作人员作为观察组，采用三色分区管理模式，比较应用效果。结果显示，相较于对照组，观察组红区核酸采样—运送—检测全程时间 (均P<0.05)、黄区核酸采样(P＝0.024)和检测时间(P<0.001)、核酸异常患者追查时间(P<0.001)均显著缩短；核酸样本漏液 (P＝0.018)、内参过少(P＝0.012)、信息错误(P＝0.014)等质量不合格的情况(P＝0.001)显著减少；患者(P<0.001)及工作人员(P<0.001)的满意度均显著提升。本研究证实三色分区管理模式可以有效缩短疫情高传播风险人群核酸标本采样—运送—检测各环节以及核酸异常患者追查的耗时，提高工作效率，改善核酸标本质量，提升患者和工作人员的满意度。

The purpose of the current study is to study the effect of in-hospital three-color zoning management mode in SARS-CoV-2 nucleic acid sample collection during the epidemic. Patients and staff involved in nucleic acid sample collection in our hospital during April 1 st to 15th April, 2022 were selected as the control group, and the original nucleic acid sample collection mode was adopted. Patients and staff involved in nucleic acid sample collection During April16th to 30th April, 2022 in our hospital were regarded as observation group which adopted the three-color zoning management mode. Compared with the control group, the whole time of nucleic acid sampling-transport-testing in the red zone (all P<0.05), the detection time (P＝0.024) and detection time (P<0.001) and the tracing time of patients with nucleic acid abnormalities (P<0.001) were significantly shortened in the observation group. Conditions of unqualified samples were significantly reduced (P＝0.001), including sample leakage (P＝0.018), lack of internal parameters (P＝0.012), and information errors (P＝0.014). Patient (P<0.001) and staff (P<0.001) satisfaction increased significantly. The three-color zoning management model can effectively shorten the time consumption of sampling-transporting-testing of nucleic acid sample collection and of the tracing of patients with nucleic acid abnormalities. This mode improved work efficiency, and the quality of nucleic acid samples, and satisfaction of patients and staff.