Research progress on the immune function changes of B lymphocytes induced by severe fever with thrombocytopenia syndrome virus infection
LI Xue1，2，*, XU Wen2，*, CHEN Weiwei2
1. School of Pharmaceutical Sciences, Binzhou Medical, Yantai 264003, Shandong Province, China; 2. Institute of Infectious Disease Medicine, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
Abstract：Sever fever with thrombocytopenia syndrome virus (SFTSV) is a novel virus discovered in recent years. Sever fever with thrombocytopenia syndrome (SFTS) is caused by SFTSV infection, characterized by high fever, thrombocytopenia, leukopenia and multiple organ function damage, with a mortality rate from 5% to 30%. There is no proven effective antiviral drugs and vaccine available now. SFTSV infection can cause immune dysfunction in patients, and B lymphocytes are one of the important target cells for SFTSV infection, but the impact of SFTSV infection on B lymphocyte function is still unclear. This article reviews research on the abnormalities and underlying mechanism of B lymphocyte functions caused by SFTSV infection, so as to promote the research progress of the immunopathological mechanism of SFTSV infection, providing a basis for a deeper understanding of the impact of SFTSV infection on B lymphocytes and the development of related diagnostic and therapeutic technologies.
李雪1，2，*，许文2，*，陈威巍2. SFTSV感染引起B淋巴细胞免疫功能改变的研究进展[J]. 微生物与感染, 2023, 18(6): 364-369.
LI Xue1，2，*, XU Wen2，*, CHEN Weiwei2. Research progress on the immune function changes of B lymphocytes induced by severe fever with thrombocytopenia syndrome virus infection. JOURNAL OF MICROBES AND INFECTIONS, 2023, 18(6): 364-369.
2023, Vol. 18 
