Abstract:Abstract:Sever fever with thrombocytopenia syndrome virus (SFTSV) is a novel virus discovered in recent years. Sever fever with thrombocytopenia syndrome (SFTS) is caused by SFTSV infection, characterized by high fever, thrombocytopenia, leukopenia and multiple organ function damage, with a mortality rate of 5%-30%. There is no proven effective antiviral drugs and vaccine available now. SFTSV infection can cause immune dysfunction in patients, and B lymphocytes are one of the important target cells for SFTSV infection, but the impact of SFTSV infection on B lymphocyte function is still unclear. This article reviews research on the abnormalities and underlying mechanism of B lymphocyte functions caused by SFTSV infection, so as to promote the research progress of the immunopathological mechanism of SFTSV infection, providing a basis for a deeper understanding of the impact of SFTSV infection on B lymphocytes and the development of related diagnostic and therapeutic technologies.
Yu XJ, Liang MF, Zhang SY, Liu Y, Li JD, Sun YL, Zhang L, Zhang QF, Popov VL, Li C, Qu J, Li Q, Zhang YP, Hai R, Wu W, Wang Q, Zhan FX, Wang XJ, Kan B, Wang SW, Wan KL, Jing HQ, Lu JX, Yin WW, Zhou H, Guan XH, Liu JF, Bi ZQ, Liu GH, Ren J, Wang H, Zhao Z, Song JD, He JR, Wan T, Zhang JS, Fu XP, Sun LN, Dong XP, Feng ZJ, Yang WZ, Hong T, Zhang Y, Walker DH, Wang Y, Li DX. Fever with Thrombocytopenia Associated with a Novel Bunyavirus in China [J]. N Engl J Med, 2011, 364(16): 1523-1532.
[2]
Kim WY, Choi W, Park SW, Wang EB, Lee WJ, Jee Y, Lim KS, Lee HJ, Kim SM, Lee SO, Choi SH, Kim YS, Woo JH, Kim SH. Nosocomial Transmission of Severe Fever With Thrombocytopenia Syndrome in Korea [J]. Clin Infect Dis, 2015, 60(11): 1681-1683.
[3]
Liu K, Cui N, Fang LQ, Wang BJ, Lu QB, Peng W, Li H, Wang LY, Liang S, Wang HY, Zhang YY, Zhuang L, Yang H, Gray GC,?de Vlas SJ, Liu W, Cao WC. Epidemiologic features and environmental risk factors of severe fever with thrombocytopenia syndrome, Xinyang, China [J]. LoS Negl Trop Dis, 2014, 8(5): e2820.
[4]
Bopp NE, Kaiser JA, Strother AE, Barrett ADT, Beasley DWC, Benassi V, Milligan GN, Preziosi MP, Reece LM. Baseline mapping of severe fever with thrombocytopenia syndrome virology, epidemiology and vaccine research and development [J]. NPJ Vaccines, 2020, 5(1): 111.
[5]
Li Z, Hu J, Cui L, Hong Y, Liu J,?Li P, Guo X, Liu W, Wang X, Qi X, Wu B, Feng Z, Shen A, Liu X, Zhao H, Tan W, Zhou J, Xing Z, Bao C. Increased Prevalence of Severe Fever with Thrombocytopenia Syndrome in Eastern China Clustered with Multiple Genotypes and Reasserted Virus during 2010-2015 [J]. Sci Rep, 2017, 7(1): 6503.
[6]
Sun JM, Zhang YJ, Gong ZY, Zhang L, Lv HK, Lin JF, Chai CL, Ling F, Liu SL, Gu SP, Zhu ZH, Zheng XH, Lan YQ, Ding F, Huang WZ, Xu JR, Chen EF, Jiang JM. Seroprevalence of severe fever with thrombocytopenia syndrome virus in southeastern China and analysis of risk factors [J]. Epidemiol Infect, 2015, 143(4): 851-6.
[7]
Zhao J, Lu QB, Li H, Yuan Y, Cui N, Yuan C, Zhang XA, Yang ZD, Ruan SM, Liu LZ, Du J, Fang LQ, Liu W. Sex Differences in Case Fatality Rate of Patients With Severe Fever With Thrombocytopenia Syndrome [J]. Front Microbiol, 2021, 12: 738808.
Wuerth JD, Weber F. Phleboviruses and the Type I Interferon Response [J]. Viruses, 2016, 8(6): 174.
[10]
Wu XD, Qi X, Liang MF, Li C, Cardona CJ, Li DX, Xing Z. Roles of viroplasm-like structures formed by nonstructural protein NSs in infection with severe fever with thrombocytopenia syndrome virus [J]. FASEB J, 2014, 28(6): 2504-16.
[11]
Kitagawa Y, Sakai M, Shimojima M, Saijo M, Itoh M, Gotoh B. Nonstructural protein of severe fever with thrombocytopenia syndrome phlebovirus targets STAT2 and not STAT1 to inhibit type I interferon-stimulated JAK-STAT signaling [J]. Microbes Infect, 2018, 20(6): 360-368.
[12]
Ning YJ, Mo Q, Feng K, Min YQ, Li MY, Hou DH, Peng C, Zheng X, Deng F, Hu ZH, Wang HI. Interferon-γ-Directed Inhibition of a Novel High-Pathogenic Phlebovirus and Viral Antagonism of the Antiviral Signaling by Targeting STAT1 [J]. Front Immunol, 2019, 10: 1182.
[13]
Liu MM, Lei XY, Yu H, Zhang JZ, Yu XJ. Correlation of cytokine level with the severity of severe fever with thrombocytopenia syndrome [J]. Virol J, 2017, 14(1): 6.
[14]
Sun LP, Hu YJ, Niyonsaba A, Tong QX, Lu L, Li HY, Jie SH. Detection and evaluation of immunofunction of patients with severe fever with thrombocytopenia syndrome [J]. Clin Exp Med, 2014, 14(4): 389-95.
Peng C, Wang H, Zhang WJ, Zheng X, Tong QX, Jie SH, Yang DL, Zhou YC. Decreased monocyte subsets and TLR4-mediated functions in patients with acute severe fever with thrombocytopenia syndrome (SFTS) [J]. Int J Infect Dis, 2016, 43: 37-42.
Li MM, Zhang WJ, Liu J, Li MY, Zhang YF, Xiong Y, Xiong SE, Zou CC, Xiong LQ, Liang BY, Lu MJ, Yang DL, Peng C, Zheng X. Dynamic changes in the immunological characteristics of T lymphocytes in surviving patients with severe fever with thrombocytopenia syndrome (SFTS) [J]. Int J Infect Dis, 2018, 70: 72-80.
[21]
Martínez-Sosa P, Mendoza L. The regulatory network that controls the differentiation of T lymphocytes [J]. Biosystems, 2013, 113(2): 96-103.
[22]
Yi XL, Li WY, Li HY, Jie SH. Circulating regulatory T cells in patients with severe fever with thrombocytopenia syndrome [J]. Infect Dis (Lond), 2015, 47(5): 294-301.
Song PX, Zheng N, Liu Y, Tian C, Wu XL, Ma XH, Chen DY, Zou X, Wang GY, Wang HR, Zhang YY, Lu SF, Wu C, Wu ZW. Deficient humoral responses and disrupted B-cell immunity are associated with fatal SFTSV infection [J]. Nat Commun, 2018, 9(1): 3328.
[25]
Yu JB, Duong VHH, Westphal K, Westphal A, Suwandi A, Grassl GA, Brand K, Chan AC, F?ger N, Lee KH. Surface receptor Toso controls B cell-mediated regulation of T cell immunity [J]. J Clin Invest, 2018, 128(5): 1820-1836.
[26]
Matsuno K, Orba Y, Maede-White K, Scott D, Feldmann F, Liang M, Ebihara H. Animal Models of Emerging Tick-Borne Phleboviruses: Determining Target Cells in a Lethal Model of SFTSV Infection [J]. Front Microbiol, 2017, 8: 104.
[27]
Hiraki T, Yoshimitsu M, Suzuki T, Goto Y, Higashi M, Yokoyama S, Tabuchi T, Futatsuki T, Nakamura K, Hasegawa H, Saijo M, Kakihana Y, Arima N, Yonezawa S. Two autopsy cases of severe fever with thrombocytopenia (SFTS) in Japan: A pathognomonic histological feature and unique complication of SFTS [J]. Pathol Int, 2014, 64(11): 569-75.
[28]
Takahashi T, Suzuki T, Hiroshige S, Nouno S, Matsumura T, Tominaga T, Yujiri T, Katano H, Sato Y, Hasegawa H. Transient Appearance of Plasmablasts in the Peripheral Blood of Japanese Patients with Severe Fever with Thrombocytopenia Syndrome [J]. J Infect Dis, 2019, 220(1): 23-27.
[29]
Suzuki T, Sato Y, Sano K, Arashiro T, Katano H, Nakajima N, Shimojima M, Kataoka M, Takahashi K, Wada Y, Morikawa S, Fukushi S, Yoshikawa T, Saijo M, Hasegawa H. Severe fever with thrombocytopenia syndrome virus targets B cells in lethal human infections [J]. J Clin Invest, 2020, 130(2): 799-812.
[30]
Park A, Park SJ, Jung KL, Kim SM, Kim EH, Kim YI, Foo SS, Kim S, Kim SG, Yu KM, Choi Y, Kim JY, Baek YH, Song MS, Kim SR, Kim SY, Jeong HW, Kim SH, Jung JU, Choi YK. Molecular Signatures of Inflammatory Profile and B-Cell Function in Patients with Severe Fever with Thrombocytopenia Syndrome [J]. mBio, 2021, 12(1): e02583-20.
Liu JW, Wang L, Feng ZL, Geng DY, Sun Y, Yuan GY. Dynamic changes of laboratory parameters and peripheral blood lymphocyte subsets in severe fever with thrombocytopenia syndrome patients [J]. Int J Infect Dis, 2017, 58: 45-51.
[33]
Wada Y, Miyamoto S, Iida S, Sano K, Sato Y, Ainai A, Saito K, Katano H, Hasegawa H, Suzuki T. Propagation of Activated B Cells by In Vitro Severe Fever With Thrombocytopenia Syndrome Virus Infection of Human Peripheral Blood Mononuclear Cells [J]. J Infect Dis, 2022, 225(2): 269-281.
[34]
Li H, Li XK, Lv SM, Peng XF, Cui N, Yang T, Yang ZD, Yuan C, Yuan Y, Yao JY, Yuan Z, Li JC, Ye XL, Zhang XA, Zhu S, Peng K, Liu W. Single-cell landscape of peripheral immune responses to fatal SFTS [J]. Cell Rep, 2021, 37(8): 110039.
[35]
Walker LM, Phogat SK, Chan-Hui PY, Wagner D, Phung P, Goss JL, Wrin T, Simek MD, Fling S, Mitcham JL, Lehrman JK, Priddy FH, Olsen OA, Frey SM, Hammond PW, Kaminsky S, Zamb T, Moyle M, Koff WC, Poignard P, Burton DR. Broad and Potent Neutralizing Antibodies from an African Donor Reveal a New HIV-1 Vaccine Targe [J]. Science, 2009, 326(5950): 285-9.
Morita R, Schmitt N, Bentebibel SE, Ranganathan R, Bourdery L, Zurawski G, Foucat E, Dullaers M, Oh S, Sabzghabaei N, Lavecchio EM, Punaro M, Pascual V, Banchereau J, Ueno H. Human blood CXCR5(+)CD4(+) T cells are counterparts of T follicular cells and contain specific subsets that differentially support antibody secretion [J]. Immunity, 2011, 34(1): 108-21.
Song PX, Zheng N, Zhang L, Liu Y, Chen TY, Bao CJ, Li ZF, Yong W, Zhang YY, Wu C, Wu ZW. Downregulation of Interferon-β and Inhibition of TLR3 Expression are associated with Fatal Outcome of Severe Fever with Thrombocytopenia Syndrome [J]. Sci Rep, 2017, 7(1): 6532.