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微生物与感染  2023, Vol. 18 Issue (6): 364-369    DOI: 10.3969/j.issn.1673-6184.2023.06.007
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SFTSV感染引起B淋巴细胞免疫功能改变的研究进展
李雪1,2,*,许文2,*,陈威巍2
1. 滨州医学院药学院,山东 烟台 264003;  2. 中国人民解放军总医院第五医学中心感染病医学部研究所,北京 100039
Research progress on the immune function changes of B lymphocytes induced by severe fever with thrombocytopenia syndrome virus infection
LI Xue1,2,*, XU Wen2,*, CHEN Weiwei2
1. School of Pharmaceutical Sciences, Binzhou Medical, Yantai 264003, Shandong Province, China; 2. Institute of Infectious Disease Medicine, Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
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摘要: 发热伴血小板减少综合征病毒(sever fever with thrombocytopenia syndrome virus,SFTSV)是近年发现的新病毒。该病毒感染引起的发热伴血小板减少综合征(sever fever with thrombocytopenia syndrome,SFTS)以高热、血小板和白细胞减少、多脏器功能损伤为主要临床特征,死亡率5%~30%。目前尚无验证有效的抗病毒药物和疫苗。SFTSV感染可引起患者免疫功能紊乱,B淋巴细胞是该病毒感染的重要靶细胞之一,但SFTSV感染对B淋巴细胞功能的影响尚不完全清楚。本文对SFTSV感染引起的B淋巴细胞免疫功能异常及其机制研究进行综述,以期促进SFTSV感染的免疫病理机制研究,为深入认识SFTSV感染对B淋巴细胞的影响,开发相关诊疗技术提供基础。
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李雪1
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陈威巍2
关键词 发热伴血小板减少综合征病毒免疫功能感染B淋巴细胞    
Abstract:Sever fever with thrombocytopenia syndrome virus (SFTSV) is a novel virus discovered in recent years. Sever fever with thrombocytopenia syndrome (SFTS) is caused by SFTSV infection, characterized by high fever, thrombocytopenia, leukopenia and multiple organ function damage, with a mortality rate from 5% to 30%. There is no proven effective antiviral drugs and vaccine available now. SFTSV infection can cause immune dysfunction in patients, and B lymphocytes are one of the important target cells for SFTSV infection, but the impact of SFTSV infection on B lymphocyte function is still unclear. This article reviews research on the abnormalities and underlying mechanism of B lymphocyte functions caused by SFTSV infection, so as to promote the research progress of the immunopathological mechanism of SFTSV infection, providing a basis for a deeper understanding of the impact of SFTSV infection on B lymphocytes and the development of related diagnostic and therapeutic technologies.
Key wordsSever fever with thrombocytopenia syndrome virus    Immunity    Infection    B lymphocytes
ZTFEL:  R558+.2  
  R373.3   
基金资助:国家重点研发计划资助 (2021YFC2301804)
通讯作者: 陈威巍   
引用本文:   
李雪1,2,*,许文2,*,陈威巍2. SFTSV感染引起B淋巴细胞免疫功能改变的研究进展[J]. 微生物与感染, 2023, 18(6): 364-369.
LI Xue1,2,*, XU Wen2,*, CHEN Weiwei2. Research progress on the immune function changes of B lymphocytes induced by severe fever with thrombocytopenia syndrome virus infection. JOURNAL OF MICROBES AND INFECTIONS, 2023, 18(6): 364-369.
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http://jmi.fudan.edu.cn/CN/10.3969/j.issn.1673-6184.2023.06.007     或     http://jmi.fudan.edu.cn/CN/Y2023/V18/I6/364

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