发热伴血小板减少综合征病毒(sever fever with thrombocytopenia syndrome virus，SFTSV)是近年发现的新病毒。该病毒感染引起的发热伴血小板减少综合征(sever fever with thrombocytopenia syndrome，SFTS)以高热、血小板和白细胞减少、多脏器功能损伤为主要临床特征，死亡率5%～30%。目前尚无验证有效的抗病毒药物和疫苗。SFTSV感染可引起患者免疫功能紊乱，B淋巴细胞是该病毒感染的重要靶细胞之一，但SFTSV感染对B淋巴细胞功能的影响尚不完全清楚。本文对SFTSV感染引起的B淋巴细胞免疫功能异常及其机制研究进行综述，以期促进SFTSV感染的免疫病理机制研究，为深入认识SFTSV感染对B淋巴细胞的影响，开发相关诊疗技术提供基础。

Sever fever with thrombocytopenia syndrome virus (SFTSV) is a novel virus discovered in recent years. Sever fever with thrombocytopenia syndrome (SFTS) is caused by SFTSV infection, characterized by high fever, thrombocytopenia, leukopenia and multiple organ function damage, with a mortality rate from 5% to 30%. There is no proven effective antiviral drugs and vaccine available now. SFTSV infection can cause immune dysfunction in patients, and B lymphocytes are one of the important target cells for SFTSV infection, but the impact of SFTSV infection on B lymphocyte function is still unclear. This article reviews research on the abnormalities and underlying mechanism of B lymphocyte functions caused by SFTSV infection, so as to promote the research progress of the immunopathological mechanism of SFTSV infection, providing a basis for a deeper understanding of the impact of SFTSV infection on B lymphocytes and the development of related diagnostic and therapeutic technologies.