Advances in studies on the role of NLRP 6 in host immunity against bacterial infection
CAO Yu1, 2, GONG Yating1, WU Shuyan1, HUANG Rui1
1. School of Biology & Basic Medical Science, Suzhou Medical College of Soochow University, Suzhou 215123, Jiangsu Province, China; 2. Laboratory Department, Children’s Hospital of Soochow University, Suzhou 215025, Jiangsu Province, China
Abstract：Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6 (NLRP 6) is one of the important intracellular pattern recognition receptors of host innate immunity and is involved in the regulation of infection, inflammation, tumor and metabolic diseases. By sensing pathogenic organisms such as bacteria, viruses, fungi, parasites and their products, such as lipoteichoic acid (LTA) of Gram-positive bacterium and viral double-stranded RNA, it can regulate the anti-infection immune effect of the body, weaken or enhance the host resistance and affect the outcome of infection. This article reviews the structure and function of NLRP 6 and its role in host immunity against bacterial infection.
曹宇1, 2，龚亚婷1，吴淑燕1，黄瑞1. NLRP 6在抗细菌感染免疫中的作用研究进展[J]. 微生物与感染, 2023, 18(6): 358-363.
CAO Yu1, 2, GONG Yating1, WU Shuyan1, HUANG Rui1. Advances in studies on the role of NLRP 6 in host immunity against bacterial infection. JOURNAL OF MICROBES AND INFECTIONS, 2023, 18(6): 358-363.
2023, Vol. 18 
