微生物与感染
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微生物与感染  2023, Vol. 18 Issue (6): 358-363    DOI: 10.3969/j.issn.1673-6184.2023.06.006
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NLRP 6在抗细菌感染免疫中的作用研究进展
曹宇1, 2,龚亚婷1,吴淑燕1,黄瑞1
1. 苏州大学苏州医学院基础医学与生物科学学院,江苏 苏州 215123;  2. 苏州大学附属儿童医院检验科,江苏 苏州 215025
Advances in studies on the role of NLRP 6 in host immunity against bacterial infection
CAO Yu1, 2, GONG Yating1, WU Shuyan1, HUANG Rui1
1. School of Biology & Basic Medical Science, Suzhou Medical College of Soochow University, Suzhou 215123, Jiangsu Province, China;  2. Laboratory Department, Children’s Hospital of Soochow University, Suzhou 215025, Jiangsu Province, China
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摘要: 含热蛋白结构域的核苷酸结合寡聚化结构域样受体蛋白 6(nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6,NLRP 6)是宿主固有免疫重要的胞内模式识别受体之一,参与机体感染、炎症、肿瘤和代谢性疾病的调节。它可通过感知细菌、病毒、真菌和寄生虫等病原生物及其产物,如革兰氏阳性菌脂磷壁酸(lipoteichoic acid,LTA)和病毒双链RNA,调节机体抗感染免疫效应,减弱或增强宿主的抵抗力,从而影响感染的转归。本文就NLRP 6的结构与功能及其在抗细菌感染免疫中的作用研究作综述。
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曹宇1
2
龚亚婷1
吴淑燕1
黄瑞1
关键词 含热蛋白结构域的核苷酸结合寡聚化结构域样受体蛋白 6细菌抗感染免疫    
Abstract:Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6 (NLRP 6) is one of the important intracellular pattern recognition receptors of host innate immunity and is involved in the regulation of infection, inflammation, tumor and metabolic diseases. By sensing pathogenic organisms such as bacteria, viruses, fungi, parasites and their products, such as lipoteichoic acid (LTA) of Gram-positive bacterium and viral double-stranded RNA, it can regulate the anti-infection immune effect of the body, weaken or enhance the host resistance and affect the outcome of infection. This article reviews the structure and function of NLRP 6 and its role in host immunity against bacterial infection.
Key wordsNucleotide-binding oligomerization domain-like receptor family pyrin domain containing 6    Bacteria    Immunity against infection
ZTFEL:  R378  
基金资助:国家自然科学基金面上项目(81971899, 31670140)
通讯作者: 黄瑞   
引用本文:   
曹宇1, 2,龚亚婷1,吴淑燕1,黄瑞1. NLRP 6在抗细菌感染免疫中的作用研究进展[J]. 微生物与感染, 2023, 18(6): 358-363.
CAO Yu1, 2, GONG Yating1, WU Shuyan1, HUANG Rui1. Advances in studies on the role of NLRP 6 in host immunity against bacterial infection. JOURNAL OF MICROBES AND INFECTIONS, 2023, 18(6): 358-363.
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http://jmi.fudan.edu.cn/CN/10.3969/j.issn.1673-6184.2023.06.006     或     http://jmi.fudan.edu.cn/CN/Y2023/V18/I6/358

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