Study on blood infection of Herbaspirillum huttiense in patient with lung adenocarcinoma
WANG Qun, ZHANG Li, WU Weixing, XIE Zhenghua
Department of Laboratory Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital & Shenzhen Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Shenzhen 518116, Guangdong Province, China
Abstract：The purpose of the current study is to analyze the identification and antimicrobial susceptibility characteristics of Herbaspirillum huttiense (H. huttiense) which was isolated from a lung adenocarcinoma patient with bloodstream infection, and review the literature in search of any similar cases of this rare condition to provide guidance for clinical treatment. The positive blood culture samples from a patient with lung adenocarcinoma after radiotherapy was smeared, gram stained and examined under microscope. At the same time, VITEK MS automatic microbial mass spectrometry system, VITEK 2 Compact automatic microbial analysis system and molecular sequencing technology were used to identify and analyze the isolate. And the antimicrobial susceptibility was determined by the broth microdilution method according to the Clinical and Laboratory Standards Institute (CLSI) guidelines for non-fermented Gram-negative bacilli. The results demonstrated that the strain was Gram-negative rods. And the colonies on the blood plate were milky, gelatinous, raised and without hemolytic. The strain was identified as H. huttiense by VITEK MS mass spectrometer and molecular sequencing technology, but identified as Burkholderia cepacia by VITEK 2 Compact. The results of antimicrobial susceptibility showed that the strain was intermediate to aztreonam, and sensitive to imipenem, meropenem, cefoperazone/sulbactam sodium, ceftazidime, cefepime, piperacillin/tazobactam and levofloxacin. This study describes the biological characteristics and the approach to diagnosis and treatment of H. huttiense, which emphasizes the importance of multiple diagnostic techniques in the identification of rare bacteria.
王群，张丽，吴卫星，谢争华. 肺腺癌患者血流感染哈特草螺菌的相关研究[J]. 微生物与感染, 2023, 18(6): 346-352.
WANG Qun, ZHANG Li, WU Weixing, XIE Zhenghua. Study on blood infection of Herbaspirillum huttiense in patient with lung adenocarcinoma. JOURNAL OF MICROBES AND INFECTIONS, 2023, 18(6): 346-352.
2023, Vol. 18 
