本文报道了1例经由小型无绿藻（Prototheca wickerhamii）所致的多处皮肤严重感染病例。通过对患者右手背糜烂处深部皮肤组织进行培养，在35℃ 5% CO2培养48h后于血平板上可见白色干燥菌落生长，经革兰染色油镜下可见呈紫色球形或卵球形菌体。念珠菌显色平板上可见浅紫色奶油样菌落生长，经乳酸酚棉兰和钙荧光白荧光染色后油镜下均可见桑葚胚状的内生孢子，最后经VITEK 2-Compact全自动微生物鉴定分析系统及VITEK MS 质谱仪鉴定结果为小型无绿藻（P. wickerhamii）。临床医生根据病情及药敏结果，先后使用伊曲康唑及伏立康唑抗真菌治疗，病人皮疹明显好转并顺利出院。

The present paper reported a case of multiple severe skin infection caused by P. wickerhamii. By culturing the deep skin tissue at the erosion site of the patient's right hand back, white dry colonies could be seen growing on the blood plate after 48 hours of cultivation at 35 ℃ and 5% CO2. Purple spherical or oval shaped bacteria bodies could be seen under the gram staining oil microscope. Light purple creamy colonies were observed on the candida colorimetric plate. After staining with lactophenol cotton blue and calcofluor white, endogenous spores resembling mulberry embryos could be seen under the oil microscope. Finally, the results of the VITEK 2-Compact fully automatic microbial identification analysis system and VITEK MS mass spectrometer identification were P. wickerhamii. The patient was given voriconazole and itraconazole for antifungal treatment based on his condition and drug sensitivity results. Luckily enough, the patient's rash improved significantly and was discharged smoothly.