Objective To explore antimicrobial resistance of lower respiratory tract infection with Stenotrophomonas maltophilia. Methods The ability of Stenotmphomonas maltophilia, isolated from clinical samples in patients with lower respiratory tract infections, to resist 14 antibiotics was measured by VITEK60 GNS from Jan.2001 - Jan.2007.Results During Jan.2001 - Jan.2007, there were133 Stenotrophomonas maltophilia strains isolated from lower respiratory tract specimens. The sensitivity of Stenotrophomonas maltophilia to the antibiotic Penicillin was the poorest. The sensitivity of Stenotrophomonas maltophilia to Cefepime was the highest as was also the case with approximately 88.0% of the Cephalosporins. However, trimethopsulfamethoxazole seemed to produce the greatest sensitivity (approximately 92.5% ) . Conclusion Stenotrophomonas maltophilia, isolated from the lower respiratory tract, is known to be highly resistance to multiple antibiotics. Trimethoprim-sulfamethoxazolemay may be the best antibiotic choice for Stenotrophomonas rrraltophilia infections. These results also indicate that Clinicans should choose antibiotics according to results attained through an antibiotic susceptibility test.