Abstract：In Sal monella , the PhoP-PhoQ two-component signal transduction system (TCS) is a maj or regulator of virulence , consisting of the trans-membrane sensor , PhoQ, and the cytoplasmic regulator , PhoP. PhoP-PhoQ can regulate Salmonella adaption to a low Mg2+ environment and other periplasmic signals , mediating transcription and expression of genes that encode proteins essential to bacterial virulence in the host cell . PhoP-PhoQ is necessary f or Salmonella in epithelium cell invasion, survival within macrophages , resistance to anti microbial peptides , modification of li pid A, function of type Ⅲ secretion system, and pathogenesis . PhoP- PhoQ can also interact with other TCSs or regulators to forma perfect regulative networkto ensure the regulation more suitable and well- rounded. Theref ore , PhoP-PhoQplays an important role in the regulation of Salmonella virulence .
陈嘉瑜; 蔡霞; 瞿涤. 沙门菌PhoP-PhoQ双组分信号转导系统[J]. 微生物与感染
, 2010, 5(4): 239-242.
CHEN Jia-Yu; CAI Xia; Qu Di. PhoP-PhoQ two-component signal transduction system in Salmonella. Journal of Microbes and Infections, 2010, 5(4): 239-242.