PhoP-PhoQ 是调控沙门菌毒力的重要双组分信号转导系统, 由组氨酸蛋白激酶PhoQ 和反应调节蛋白PhoP 组成。PhoP-PhoQ 可调节沙门菌对Mg2 + 及其他周质环境的适应性, 并调控沙门菌感染中毒力基因的转录和表达。PhoP-PhoQ 调控的毒力基因参与沙门菌对上皮细胞的侵袭、胞内生存、对抗菌肽的抵抗反应、脂质A 的修饰、Ⅲ型分泌系统效应蛋白的分泌等环节。PhoP-PhoQ 还可与其他双组分信号转导系统或调节子合作, 调控沙门菌的毒力。因此,PhoP-PhoQ 双组分信号转导系统在沙门菌的毒力调控中发挥重要作用。

In Sal monella , the PhoP-PhoQ two-component signal transduction system (TCS) is a maj or regulator of virulence , consisting of the trans-membrane sensor , PhoQ, and the cytoplasmic regulator , PhoP. PhoP-PhoQ can regulate Salmonella adaption to a low Mg²⁺ environment and other periplasmic signals , mediating transcription and expression of genes that encode proteins essential to bacterial virulence in the host cell . PhoP-PhoQ is necessary f or Salmonella in epithelium cell invasion, survival within macrophages , resistance to anti microbial peptides , modification of li pid A, function of type Ⅲ secretion system, and pathogenesis . PhoP- PhoQ can also interact with other TCSs or regulators to forma perfect regulative networkto ensure the regulation more suitable and well- rounded. Theref ore , PhoP-PhoQplays an important role in the regulation of Salmonella virulence .