Abstract：Entrance of human immunodeficiency virus type 1 (HIV-1) into cells is mediated by envelope glycoprotein (Env) ，which contains a receptor-binding unit gp120 and a membrane-fusion unit gp41. HIV-1 gp41 consists of three major functional regions: ectodomain, membrane-spanning domain (MSD) and endodomain. The ectodomain is a structural basis for membrane fusion during viral infection; the hydrophobic residues of MSD anchor Env to the bilayer membrane; and the endodomain plays multiple functions in viral infection, replication and assembly. The most important motifs in the endodomain are three lentivirus lytic peptides (LLP 1-3), two Tyr-contained motifs (Y712XXL and Y802W803), and a dileucine motif (LL856/857). Additionally, the topological change of the endodomain including Kennedy epitope shows there are interactions among three regions of gp41. The progress in function-structure of gp41 not only improves the understanding to the replication and pathogenesis of HIV-1 but also provides some insights into the development of new antiviral drugs.
姚茜茜; 吕钧; 叶荣. 人类免疫缺陷病毒1型gp41结构与功能的研究进展[J]. 微生物与感染
, 2011, 6(4): 238-247.
YAO Qian-Qian; LV Jun; YE Rong. Progress in the structure and function of human immunodeficiency virus type 1 gp41. Journal of Microbes and Infections, 2011, 6(4): 238-247.
