Abstract：In clinical treatment, loss of serum hepatitis B virus e antigen (HBeAg) and appearance of anti-HBe ( HBeAg seroconversion ) is one of the important criteria for therapeutic efficacy of chronic hepatitis B. Herein, the history of discovery of HBeAg, and the biological and medical implication of this hepatitis B virus (HBV) encoded protein are presented. In addition, the immunogenicity of HBeAg and core antigen (HBcAg) is compared, and the immunological basis as well as the importance of HBeAg seroconversion is analysed.
闻玉梅. 乙型肝炎病毒e抗原的生物学功能及血清学转换的免疫学基础[J]. 微生物与感染
, 2011, 6(4): 193-198.
WEN Yu-Mei. The biological function of hepatitis B virus e antigen and its immunological basis of seroconversion. Journal of Microbes and Infections, 2011, 6(4): 193-198.