乙型肝炎病毒核心蛋白变构调节剂的研究进展

陈诗琦; 毛日成; 张继明

doi:10.3969/j.issn.1673-6184.2020.05.009

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微生物与感染 ›› 2020, Vol. 15 ›› Issue (5) : 322-330. DOI: 10.3969/j.issn.1673-6184.2020.05.009

综述

乙型肝炎病毒核心蛋白变构调节剂的研究进展

陈诗琦，毛日成，张继明

作者信息 +

Research of hepatitis B virus core protein’s allosteric modulators

CHEN Shiqi, MAO Richeng, ZHANG Jiming

Author information +

文章历史 +

摘要

由于乙型肝炎病毒(hepatitis B virus，HBV)的共价闭合环状DNA的持续存在和病毒介导的宿主免疫反应钝化，导致慢性乙型肝炎病毒感染很难治愈。现有的核苷(酸)类似物或聚乙二醇干扰素疗法难以实现高比率的HBV表面抗原清除。目前正在研发的核心蛋白变构调节剂有望大幅度降低血清表面抗原。本文就HBV核心蛋白的结构、功能以及核心蛋白变构调节剂的分类、应用前景等方面进行综述。

Abstract

Chronic hepatitis B virus infection is difficult to cure due to the persistence of covalently closed circular DNA and viral-mediated inactivation of host immune responses. Existing nucleoside (acid) analogs or pegylated interferon therapy are difficult to achieve a high ratio of HBV surface antigen clearance. This article reviews the structure and function of HBV core protein, the classification and application prospects of core protein allosteric modulators.

导出引用

陈诗琦，毛日成，张继明. 乙型肝炎病毒核心蛋白变构调节剂的研究进展[J]. 微生物与感染. 2020, 15(5): 322-330 https://doi.org/10.3969/j.issn.1673-6184.2020.05.009

CHEN Shiqi, MAO Richeng, ZHANG Jiming. Research of hepatitis B virus core protein’s allosteric modulators[J]. Journal of Microbes and Infections. 2020, 15(5): 322-330 https://doi.org/10.3969/j.issn.1673-6184.2020.05.009

中图分类号： R373.2＋1 R512.6＋2