Modeling human immunodeficiency virus infection through mucosa and other barrier systems with Transwell
LIN Guang-Zheng1; QIU Jia-Yin2; LIU Shu-Wen2; LI Lin2
1. First School of Clinical Medical Sciences, Guangzhou 510515, China; 2. School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, 510515, China
Abstract：Transwell is a device widely used for simulating mucosal and physiologic barrier systems, such as human reproductive tract mucosa, rectal mucosa, blood-brain barrier and blood-retina barrier in vitro. This device has been used to study he process of human immunodeficiency virus (HIV) entering into the body and to help us to illustrate , the mechanism of HIV infection. The system is also being used to facilitate the discovery of new vaccines and drugs for HIV. This review covers the current progresses of transwell applications in HIV-related studies.
林光正1; 裘佳寅2; 刘叔文2; 李琳2. Transwell技术模拟人类免疫缺陷病毒感染黏膜及其他屏障系统的应用[J]. 微生物与感染
, 2012, 7(2): 105-110.
LIN Guang-Zheng1; QIU Jia-Yin2; LIU Shu-Wen2; LI Lin2. Modeling human immunodeficiency virus infection through mucosa and other barrier systems with Transwell. Journal of Microbes and Infections, 2012, 7(2): 105-110.
