New understanding of hepatitis B virus resistance mechanisms to nucleos(t)ide analogues in treatment of chronic hepatitis B
FAN Zhi-Yuan1, YU De-Min2, ZHANG Xin-Xin2
1. Ruijin College o[ Clinical Medicine, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; 2. Department of Infectious Diseases, Ruijin Hospital , Shangghai Jiao Tong University School of Medicine , Shanghai 200025, China
Abstract:Nucleos(t)ide analogue therapy is currently the main method of antiviral treatment for chronic hepatitis B (CHB). A comprehensive understanding of the resistance mechanisms of hepatitis B virus (HBV) can not only provide CHB patients with personalized drug prevention measures but also improve the efficacy of prognosis. The cunent progress on HBV resistance to nucleos( t) ide analogues has been reviewed in this paper.
范志远1,于德敏2 ,张欣欣2. 对乙型肝炎病毒耐核昔(酸)类似物机制的新认识[J]. 微生物与感染
, 2012, 7(4): 250-254.
FAN Zhi-Yuan1, YU De-Min2, ZHANG Xin-Xin2. New understanding of hepatitis B virus resistance mechanisms to nucleos(t)ide analogues in treatment of chronic hepatitis B. Journal of Microbes and Infections, 2012, 7(4): 250-254.