Abstract：Highly active antiretroviral therapy (HAART) has driven human immunodeficiency virus (HIV) to undetectably low levels in the blood and improved life quality of HIV / acquired immunodeficiency syndrome (AIDS) patients. However, the eradication of HIV-1 is hindered by the persistence of long-lived, latently infected memory CD4 T cells and the formation of viral reservoirs. Research on HIV reservoir eradication mainly focus on gene therapy , drug treatment targeting latently HIV-1-infected cells or directly reactivating the latent viruses, which are easier to be killed by antiviral therapy. In this review , the recent research progress on HIV reservoir and its eradication is summarized.
何涌泉，孟哲峰，张晓燕. 人类免疫缺陷病毒潜伏库的形成与清除[J]. 微生物与感染
, 2012, 7(4): 243-249.
HE Yong-Quan, MENG Zhe-Feng, ZHANG Xiao-Yan. Research progress on human immunodeficiency virus reservoir and its eradication. Journal of Microbes and Infections, 2012, 7(4): 243-249.
