1.General Department, Luotian First People’s Hospital, Hubei Province, Huanggang 438600, China; 2. Department of Clinical Microbiology and Immunology, Third Military Medical University, Chongqing 400038, China
Abstract：Melioidosis, caused by the inoculation, inhalation and ingestion of Burkholderia pseudomallei, is a classical tropical amphixenosis characterized by multi-abscess , tough pneumonia and fatal septicemia. The mortality rate of this disease is up to 40%. Its endemic regions are mainly among North Australia, Southeast Asia, with sporadic cases reported from North America and other areas. Melioidosis may have a wide range of clinical manifestations, varying from an acute fulminant septic illness to a chronic infection. High misdiagnosis rate, high resistance rate and long period of antibiotic therarapy combined with high relapse rate are the major barriers to treatment . With the globalization and increasing risk of imported cases, it is necessary to effectively prevent and cure melioidosis. The current research progress and clinical advice are summarized in this paper.