假丝酵母（俗称念珠菌）是人类重要的条件致病性真菌，可导致人体浅表组织感染，甚至入侵血流引起念珠菌血症和播散性念珠菌病。黏附是念珠菌机会性感染的第1步，该过程受黏附蛋白的精确调控。糖基磷脂酰肌醇锚定细胞壁蛋白(GPI-CWP)家族中有许多成员参与调控念珠菌的黏附。本文就几种重要的念珠菌黏附相关GPI-CWP：凝集样序列(Als)、菌丝壁蛋1 (Hwp1)、上皮细胞黏附素(Epa)、聚苯乙烯黏附增强蛋白1(Eap1)等的致病机制展开综述。

Candida species are the most prevalent opportunistic fungal pathogens in humans causing superficial and serious systemic infections. The infection process can be divided into three stages: adhesion, invasion, and host cell damage. Adhesion is the first stage of invasive Candida infection process and is precisely controlled by a lot of adhesins. Many of these adhesion-related proteins are members of glycosylphosphatidylinositol-anchored cell wall protein (GPI-CWP) family. This review is intended to summarize some important adhesion related to GPI-CWP: agglutinin-like sequence (Als), hyphal wall protein 1 (Hwp1), epithelial adhesin (Epa), and enhanced adherence to polystyrene 1 (Eap1).