The pathogens and multiple-locus variable-number tandem repeat analysis of tuberculous lymphadenitis in infants
DENG Gui-Lin1, QIAN Xue-Qin1, WU Jie2, SHEN Xing2, ZHANG Jun1, LU Shui-Hua1, SHEN Fang1
1. Shanghai Public Health Clinical Center Affiliated to Fudan University, Shanghai 201508, China; 2. Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China
Abstract：The paper aims to determine the main pathogen causing tuberculous lymphadenitis in infants. A total of 79 lymph node biopsies from 73 infants age 0-3 were conducted Mycobacterium tuberculosis (M. tuberculosis) identification, amplification of RD1, RD9 and RD10, and multiple-locus variable-number tandem repeat analysis (MLVA). The results showed that the main pathogen of tuberculous lymphadenitis in infants was bacillus Calmette-Guérin (BCG) (95.9%), followed by M. tuberculosis (4.1%). There were 4 genotypes including 3 independent genotypes (M. tuberculosis) and 1 genotype cluster analyzed by MLVA. The BCG isolated from clinical samples had no difference.
邓桂林1，钱雪琴1， 武洁2,沈鑫2， 张军1,卢水华1，沈芳1. 婴幼儿淋巴结核病原体及多位点可变数目串联重复序列分析[J]. 微生物与感染, 2014, 9(2): 89-95.
DENG Gui-Lin1, QIAN Xue-Qin1, WU Jie2, SHEN Xing2, ZHANG Jun1, LU Shui-Hua1, SHEN Fang1. The pathogens and multiple-locus variable-number tandem repeat analysis of tuberculous lymphadenitis in infants. JOURNAL OF MICROBES AND INFECTIONS, 2014, 9(2): 89-95.
